Population
Computational models of coupled myocyte electromechanics representing cells from the epicardial…
Design
Preclinical
Key result
Integrative computational simulations illustrated a previously unrecognized role of the transient outward potassium current in mechanical function and suggested additional heterogeneities affecting crossbridge cycling rates.
Authors
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Hypothesis-generating for ventricular electromechanics in animals; leaves open translation to human physiology or therapy.
Computational modeling reveals that transient outward potassium current and crossbridge cycling rate heterogeneities contribute to transmural differences in left ventricular myocyte electromechanics.
Campbell et al. (2008) studied Heterogeneous electromechanical behaviour in myocardium. Integrative computational models of coupled myocyte electromechanics was evaluated on Sources of heterogeneous electromechanical behaviour. Integrative computational simulations illustrated a previously unrecognized role of the transient outward potassium current in mechanical function and suggested additional heterogeneities affecting crossbridge cycling rates.