Key result
Integrative computational simulations illustrated a previously unrecognized role of the transient outward potassium current in mechanical function and suggested additional heterogeneities affecting crossbridge cycling rates.
Computational modeling reveals that transient outward potassium current and crossbridge cycling rate heterogeneities contribute to transmural differences in left ventricular myocyte electromechanics.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for ventricular electromechanics in animals; leaves open translation to human physiology or therapy.
The mechanical properties of myocardium vary across the transmural aspect of the left ventricular wall. Some of these functional heterogeneities may be related to differences in excitation-contraction coupling characteristics that have been observed in cells isolated from the epicardial, mid-myocardial and endocardial regions of the left ventricle of many species, including canine. Integrative models of coupled myocyte electromechanics are reviewed and used here to investigate sources of heterogeneous electromechanical behaviour in these cells. The simulations (i) illustrate a previously unrecognized role of the transient outward potassium current in mechanical function and (ii) suggest that there may also exist additional heterogeneities affecting crossbridge cycling rates in cells from different transmural regions.
No takes yet. Share an insight, caveat, or question.
Campbell et al. (2008) studied Heterogeneous electromechanical behaviour in myocardium. Integrative computational models of coupled myocyte electromechanics was evaluated on Sources of heterogeneous electromechanical behaviour. Integrative computational simulations illustrated a previously unrecognized role of the transient outward potassium current in mechanical function and suggested additional heterogeneities affecting crossbridge cycling rates.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: