November 1, 1999Journal of Biological ChemistryOpen Access

Nitric-oxide Synthase Is a Mechanical Signal Transducer That Modulates Talin and Vinculin Expression

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Population

Muscle cells in vivo and in vitro

Design

Preclinical

Authors

JTJames G. TidballHeart Failure / Cardiomyopathy MSMelissa J. SpencerUniversity of California, Los Angeles MWM. WehlingHeidelberg University

Discussion

Member takes

Implication

No immediate clinical implications; leaves open whether NO-PKG targeting alters focal adhesions in human cardiovascular disease.

Structured PICO

Population

Muscle cells in vivo and in vitro

Intervention

Mechanical stimulation

Outcome

Expression of vinculin and talinsurrogate

Mechanical stimuli increase vinculin and talin expression in muscle cells via a nitric oxide and protein kinase G-dependent pathway, with mRNA localized at myotendinous junctions.

Cite This Study

Tidball et al. (1999) studied this question.

synapsesocial.com/papers/6a778a8da0847c3df1ec85d8 https://doi.org/10.1074/jbc.274.46.33155

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Nitric-oxide Synthase Is a Mechanical Signal Transducer That Modulates Talin and Vinculin Expression

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nitric-oxide Synthase Is a Mechanical Signal Transducer That Modulates Talin and Vinculin Expression

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider