Key result
Weight reduction induced by laparoscopic adjustable gastric banding significantly improved metabolic parameters but did not improve endothelial function or arterial stiffness after 4 years.
Why the study?
Does laparoscopic adjustable gastric banding (LAGB) improve arterial stiffness and endothelial function in morbidly obese Caucasian subjects?
Cohort (n=48)
No
Does laparoscopic adjustable gastric banding (LAGB) improve arterial stiffness and endothelial function in morbidly obese Caucasian subjects?
Absolute Event Rate: 7.12% vs 6.58%
p-value: p=0.153
Weight reduction induced by laparoscopic adjustable gastric banding over 4 years improved metabolic parameters but did not improve endothelial function or arterial stiffness in morbidly obese patients.
Metabolic gains from gastric banding do not improve endothelial function at 4 years; hypothesis-generating and should not change practice.
OBJECTIVE: To determine the long-term effect of weight loss on arterial stiffness, metabolic parameters in morbidly obese patients who underwent laparoscopic adjustable gastric banding (LAGB). SUBJECTS: Forty-eight morbidly obese Caucasian subjects underwent LAGB from January 2009 to January 2010 and completed 4 years follow-up. MEASUREMENTS: Patients were evaluated for body mass index (BMI), waist circumference, arterial blood pressure (BP), metabolic factors: leptin, adiponectin, glucose, glycated haemoglobin (HbA1c), insulin. Endothelial function - evaluated as reactive hyperemic index (RHI). Arterial stiffness - determined by cardio - ankle vascular index (CAVI). RESULTS: 2.05±0.42 (p=0.086). CONCLUSION: Weight reduction induced by LAGB was associated with changes in body weight and metabolic parameters, but it was no improvement on endothelial function and arterial stiffness.
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Aistė Galkinė (2018) conducted a cohort in Morbid obesity (n=48). Laparoscopic adjustable gastric banding vs. Baseline was evaluated on Mean cardio-ankle vascular index (CAVI) at 4 years (p=0.153). Weight reduction induced by laparoscopic adjustable gastric banding significantly improved metabolic parameters but did not improve endothelial function or arterial stiffness after 4 years.
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