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November 18, 2009Caries Research

Plaque Inhibition by a Combination of Zinc Citrate and Sodium Lauryl Sulfate

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Authors

EGElin GiertsenUniversity of OsloASA. Aa. ScheieUniversity of OsloGRGunnar RöllaNational Institutes of Health

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Implication

Controlled trial reveals reduced dental plaque accumulation in healthy volunteers, suggesting an additive antiplaque effect of combined zinc and detergent.

Key Points

  • To evaluate the solubility and additive inhibitory effects of combining zinc citrate and sodium lauryl sulfate on bacterial growth and dental plaque accumulation.
  • In vitro bacteriological tests evaluated growth inhibition of Streptococcus sobrinus OMZ 176 and Streptococcus sanguis ATCC 10556, and atomic absorption spectrophotometry quantified zinc solubility.
  • Seven volunteers completed 3 days of twice-daily 10 ml rinses with aqueous solutions of 12.0 mM Zn2+ from zinc citrate, 34.7 mM sodium lauryl sulfate (SLS), or their combination (14.4 mM Zn2+ and 34.7 mM SLS) versus placebo without mechanical oral hygiene.
  • In vitro, SLS increased zinc citrate solubility from 12.0 mM to 14.4 mM solubilized zinc after 48 hours and exhibited additive inhibition of bacterial growth.
  • Compared to placebo, individual rinses of SLS and zinc citrate increased plaque index score 0 frequency by 52.9% and 98.3%, while reducing scores 2 or 3 by 36.9% and 55.7%, respectively (p < 0.05).
  • The combination of zinc citrate and SLS produced a threefold increase in plaque index score 0 and a 70.5% reduction in plaque index scores 2 or 3 (p < 0.05).

Cite This Study

Giertsen et al. (2009) studied this question.

synapsesocial.com/papers/6a778d05f6b553d308ae92e2https://doi.org/10.1159/000261192
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