Key result
A brief bout of exercise in hypoxia significantly impaired the ventricular filling rate response during post-exercise muscle ischemia compared to normoxia (31.33 vs. 81.52 ml/s, p=0.003).
Why the study?
The hemodynamic consequences of exercise in hypoxia have not been completely investigated, prompting this study of the hemodynamic effects of contemporary normobaric hypoxia and metaboreflex activation.
Does a brief bout of exercise in hypoxia reduce ventricular filling rate and stroke volume response during muscle metaboreflex activation in healthy males?
Population
Eleven physically active, healthy males
Comparison
Normobaric hypoxia (FiO2 13.5%) vs normoxia during exercise and metaboreflex activation
Design
Randomized crossover trial
Authors
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May caution hypoxic exercise in cardiac patients; leaves open mechanisms and clinical relevance in disease states.
RCT (n=11)
Single-blind
Randomly assigned
No
Does a brief bout of exercise in hypoxia reduce ventricular filling rate and stroke volume response during muscle metaboreflex activation in healthy males?
Absolute Event Rate: 31.33% vs 81.52%
p-value: p=0.003
A brief bout of exercise in hypoxia impairs cardiac filling rate and stroke volume during metaboreflex activation in healthy males, highlighting that cardiac pre-load is highly sensitive to hypoxic stimuli.
Mulliri et al. (2020) conducted an RCT in Healthy (n=11). Exercise in normobaric hypoxia (FiO2 13.5%) vs. Exercise in normoxia (FiO2 21.0%) was evaluated on Ventricular filling rate response during post-exercise muscle ischemia (p=0.003). A brief bout of exercise in hypoxia significantly impaired the ventricular filling rate response during post-exercise muscle ischemia compared to normoxia (31.33 vs. 81.52 ml/s, p=0.003).
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