G proteins are central to the transduction of many receptor signals. I review the "firsts" that have led to our current knowledge and delineate some of the issues being investigated in several laboratories worldwide.--Birnbaumer, L. Transudction of receptor signal into modulation of effector activity by G proteins: the first 20 years or so...FASEB J. 4:3068-3078; 1990.
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Lutz Birnbaumer (1990) studied this question.