Key result
Minimally invasive aortic valve replacement using single-dose cold modified Bretschneider solution resulted in lower average postoperative CPK-MB levels (47 U/L) compared to conventional replacement (65 U/L).
Why the study?
Does single-dose cold modified Bretschneider solution provide adequate myocardial protection in patients with aortic valve stenosis and left ventricular hypertrophy undergoing aortic valve replacement?
Observational (n=173)
No
Does single-dose cold modified Bretschneider solution provide adequate myocardial protection in patients with aortic valve stenosis and left ventricular hypertrophy undergoing aortic valve replacement?
Answers are grounded in this paper and cite their sources.
A single dose of cold modified Bretschneider solution provides safe and effective myocardial protection during both conventional and minimally invasive aortic valve replacement in patients with aortic stenosis and left ventricular hypertrophy.
Summary Aortic valve stenosis (AS) is predominantly caused by degenerative calcification in patients over 70 years. It obstructs the left ventricular outflow tract. The result is concentric left ventricular hypertrophy (LVH) wall stress and ischemia-induced myocardial fibrosis. [1] According to the European Association of Cardiothoracic Surgery, all high-grade AS patients are indicated for Aortic valve intervention [2]. One of the most recommendable methods for myocardial protection during surgical aortic valve replacement is antegrade delivery of cold crystalloid cardioplegia. Our retrospective study included 173 operated patients with AS and LVH. We observed the MB fraction of the enzyme creatine phosphokinase (CPK-MB) as a postoperative marker for myocardial hypoprotection in different patients. Our results showed that a single dose of modified Bretschnaider solution provided safe and long enough myocardial protection during conventional and minimally invasive aortic valve replacement in patients with AS and LVH [3].
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Uzov et al. (2021) conducted an observational in Aortic valve stenosis and left ventricular hypertrophy (n=173). Minimally invasive aortic valve replacement with single-dose cold modified Bretschneider solution vs. Conventional aortic valve replacement with single-dose cold modified Bretschneider solution was evaluated on Postoperative CPK-MB level on the second postoperative day (U/L). Minimally invasive aortic valve replacement using single-dose cold modified Bretschneider solution resulted in lower average postoperative CPK-MB levels (47 U/L) compared to conventional replacement (65 U/L).
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