Key result
Offspring of hypertensive parents had significantly lower SDNN (125.70 vs 141.90 ms) and altered frequency domain parameters compared to offspring of normotensive parents, indicating early cardiac autonomic imbalance.
Why the study?
Does a parental history of hypertension alter cardiac autonomic activity (HRV) in healthy young male offspring?
Cross-Sectional (n=200)
No
Does a parental history of hypertension alter cardiac autonomic activity (HRV) in healthy young male offspring?
Absolute Event Rate: 125.7% vs 141.9%
p-value: p=<0.0001
Healthy young male offspring of hypertensive parents exhibit early signs of cardiac autonomic imbalance, characterized by increased sympathetic and decreased parasympathetic activity, despite having normal resting blood pressure.
May support early autonomic screening in offspring of hypertensives; leaves open predictive value for incident hypertension.
Hypertension is a disease which affects almost entire organ systems of the body therefore it becomes essential to diagnose hypertension at an early stage so that the preventive measures can be employed. Heart Rate Variability (HRV) is used for the prediction, diagnosis and prevention of many cardiovascular dysfunctions. The aim of this study was to record basal Heart Rate (HR), Blood Pressure (BP) and HRV in offsprings of normotensive parents and hypertensive parents and compare the results between these two groups. This study was conducted on 200 subjects of age between 18 to 26 years. They were divided into two groups: control group (100; offsprings of normotensive parents) and study group (100; offsprings of hypertensive parents). The HR and BP values were measured by automatic heart rate and blood pressure measuring machine, Accusure TD 3127, Taiwan whereas HRV was recorded using RMS Polyrite D, (version 2.4), India in both the groups. Statistical analysis was done by student's unpaired t-test using GraphPad Prism 5 software version 5.03 and P values less than 0.05 was considered to be statistically significant. The HR and BP values were high in study group in respect to control group but were not statistically significant. HRV analysis has two components: time domain and frequency domain. The values of time domain parameters were insignificantly less in study group compared to control group but only Standard Deviation of Normal-to-Normal intervals (SDNN) was found to be highly statistically significant. Among the frequency domain, Low and High Frequency in normalized units (LFnu & HFnu) were statistically higher and lower respectively in study group when compared to control group. Our results indicate that there was an increased sympathetic and decreased parasympathetic activity in the study group at resting level. These findings are an early marker of cardiovascular impairment in individuals with parental history of hypertension.
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Sharma et al. (2018) conducted a cross-sectional in Parental history of hypertension (n=200). Parental history of hypertension vs. Offspring of normotensive parents was evaluated on Standard Deviation of Normal-to-Normal intervals (SDNN) (p=<0.0001). Offspring of hypertensive parents had significantly lower SDNN (125.70 vs 141.90 ms) and altered frequency domain parameters compared to offspring of normotensive parents, indicating early cardiac autonomic imbalance.
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