There are species-specific sex differences in the renal excretion of zenarestat, present in rodents but absent in dogs and humans.
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Rodent sex differences in zenarestat excretion do not apply to humans; leaves open species-specific renal transport mechanisms for further study.
Mice show a sex difference in the excretion of zenarestat similar to that seen in rats, but dogs and humans show no significant sex difference. 2. Female rats and mice, and both sexes of dogs and humans, appear to possess an active secretory mechanism in the renal excretion of zenarestat, which is lacking or relatively inactive in male rats and mice.
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Tanaka et al. (1992) studied this question.
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