Integrin regulation of caveolin function

Introduction Caveolae mediate signalling through direct and indirect mechanisms Signalling pathways at rafts: targeting by integrins Integrin triggered CEMM internalization is mediated by caveolae Dual role of caveolin Y14 phosphorylation: endocytosis vs. cell migration Conclusions Abstract Caveolae are unique organelles that are found in the plasma membrane of many cell types. They participate in various processes such as lipid recycling, cellular signalling and endocytosis. A variety of signalling molecules localize to caveolae in response to various stimuli, providing a potential mechanism for the spatial regulation of signal transduction pathways. Caveolin‐1, a constitutive protein of caveolae, has been implicated in the regulation of cell growth, lipid trafficking, endocytosis and cell migration. Phosphorylation of caveolin‐1 on Tyr 14 is involved in integrin‐regulated caveolae trafficking and also in signalling at focal adhesions in migrating cells. In this review, we focus on recent studies that describe the role of caveolin‐1 in integrin signal transduction, and how this interplay links extracellular matrix anchorage to cell proliferation, polarity and directional migration.