Why the study?
Are ACE and ecNOS DNA polymorphisms associated with an increased risk of developing late-onset Alzheimer's disease?
Population
867 individuals, comprising 350 patients with late-onset Alzheimer's disease, 400 healthy controls younger…
Comparison
Presence of ACE and ecNOS DNA polymorphisms vs Healthy controls without Alzheimer's disease
Design
Case-control
Authors
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ACE-I allele may confer modest late-onset Alzheimer's risk; hypothesis-generating observation requires prospective replication.
Are ACE and ecNOS DNA polymorphisms associated with an increased risk of developing late-onset Alzheimer's disease?
The ACE-I allele is associated with a slightly increased risk of developing late-onset Alzheimer's disease.
Álvarez et al. (1999) studied this question.
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