Key result
In vitro autoradiography of rat brain revealed that structures related to central actions of Ang II contain exclusively AT-1 receptors, whereas other specific regions contain predominantly AT-2 receptors.
Authors
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Suggests receptor-specific central Ang II effects in rats; extends preclinical mapping but leaves open human translation.
Song et al. (1992) studied this question. In vitro autoradiography mapping was evaluated on Distribution of AT-1 and AT-2 receptor subtypes in rat brain. In vitro autoradiography of rat brain revealed that structures related to central actions of Ang II contain exclusively AT-1 receptors, whereas other specific regions contain predominantly AT-2 receptors.
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