Key result
Aliskiren, a direct renin inhibitor, may have protective effects against different types of nephropathy such as acute kidney injury, diabetic nephropathy, and hypertensive nephropathy.
Why the study?
Inhibition of the RAAS impedes the development of renal diseases, and aliskiren, as a direct renin inhibitor blocking the RAAS at its first step, may be effective for renal disease management.
Does aliskiren provide renoprotective effects in patients with or models of renal disease?
Does aliskiren provide renoprotective effects in patients with or models of renal disease?
This narrative review highlights the potential of aliskiren, a direct renin inhibitor, to provide comprehensive renoprotection across various nephropathies by blocking the RAAS cascade at its origin.
AngII's non-hemodynamic renal effects may shape cardiorenal risk; leaves open targeted RAAS modulation beyond current blockade.
The renin–angiotensin–aldosterone system (RAAS) cascade has a significant effect on several systems. Angiotensin II (AngII) has appeared as not only a vasoactive peptide but also as a multifunctional cytokine that displays several non-hemodynamic properties beyond renal hemodynamic properties. The kidney includes total components of the RAAS such as aldosterone and AngII not only adjust renal hemodynamics and reabsorption of sodium but also activating various inflammatory and fibrotic responses. Inhibition of the RAAS is one of the most potent methods to impede the development of renal diseases such as chronic kidney disease (CKD) and its related problems such as high blood pressure and heart disorders. Aliskiren, an octanamide, nonpeptide piperidine, orally, active, first commercially available, and direct renin inhibitor (DRI), impedes RAAS and operates by attaching to the active sites of renin and may be effective for the management of renal disease because of blocking the RAAS at its point of start and most sensitive step. Based on numerous studies, aliskiren is the greatest powerful inhibitor of AngII extents among RAAS inhibitors, even though it is unable to prevent the (pro) renin receptor-mediated extracellular signal-regulated kinase 1 and 2 (ERK1/2) activations. In this review, it is described renoprotective effects of aliskiren against different types of nephropathy such as acute kidney injury, diabetic nephropathy, and hypertensive nephropathy.
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Roshan et al. (2022) conducted a review in Renal disease. Aliskiren was evaluated. Aliskiren, a direct renin inhibitor, may have protective effects against different types of nephropathy such as acute kidney injury, diabetic nephropathy, and hypertensive nephropathy.
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