Key result
Aliskiren treatment in Wistar rats with 2K1C hypertension reestablished AT1 receptor expression, decreased apoptosis and autophagy, and improved cell aspects in the adrenal glomerular zone.
Why the study?
The study aimed to analyze the structural and ultrastructural morphophysiology of the adrenal glomerular zone after treatment with aliskiren in Wistar rats with 2K1C hypertension.
Population
Wistar rats with 2K1C hypertension
Comparison
Aliskiren treatment vs no treatment/controls
Design
Animal experimental study
Authors
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Aliskiren may improve adrenal remodeling in renovascular hypertension models; leaves open translation to human secondary hypertension.
Matos et al. (2020) studied 2K1C hypertension. Aliskiren was evaluated on Structural and ultrastructural morphophysiology of the adrenal glomerular zone, cellular apoptosis, nuclear cell proliferation, and AT1 receptor expression. Aliskiren treatment in Wistar rats with 2K1C hypertension reestablished AT1 receptor expression, decreased apoptosis and autophagy, and improved cell aspects in the adrenal glomerular zone.
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