Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 29, 2010AJP Renal Physiology

Persistent antihypertensive effect of aliskiren is accompanied by reduced proteinuria and normalization of glomerular area in Ren-2 transgenic rats

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does aliskiren provide persistent antihypertensive and organoprotective effects compared to losartan in Ren-2 transgenic rats?

Population

Young (32 days old) and adult (100 days old) heterozygous Ren-2 transgenic rats (TGR)

Comparison

Aliskiren 10 mg/kg/day via osmotic minipumps for… vs Losartan 5 mg/kg/day in drinking water for 28…

Design

Preclinical

Follow-up

Up to 70 days of treatment plus 12 days of withdrawal

Authors

DRDan RakušanInstitute of Clinical and Experimental MedicinePKPetr KujalCharles UniversityHKHerbert J. KramerUniversity of Siena

Discussion

Loading...

Member takes

Implication

Aliskiren's persistent effects in Ren-2 rats should not inform clinical decisions; leaves open translation to human hypertension therapy.

Structured PICO

Does aliskiren provide persistent antihypertensive and organoprotective effects compared to losartan in Ren-2 transgenic rats?

P
Population
Young (32 days old) and adult (100 days old) heterozygous Ren-2 transgenic rats (TGR)
I
Intervention
Aliskiren 10 mg/kg/day via osmotic minipumps for 28 days (young rats) or 70 days (adult rats)
C
Comparator
Losartan 5 mg/kg/day in drinking water for 28 days (young rats) or 70 days (adult rats), and untreated TGR
O
Outcome
Blood pressure, cardiac hypertrophy, proteinuria, and tissue/plasma angiotensin II levelssurrogate

Aliskiren provides persistent antihypertensive and organoprotective effects, including reduced proteinuria and normalized glomerular size, even after treatment withdrawal in a transgenic rat model of hypertension.

Cite This Study

Rakušan et al. (2010) studied this question.

synapsesocial.com/papers/6a708f18ac440176ef293735https://doi.org/10.1152/ajprenal.00259.2010

Topics

Hypertension management
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Aliskiren-Binding Increases the Half Life of Renin and Prorenin in Rat Aortic Vascular Smooth Muscle Cells2008 · 94 citations
  2. 2Podocyte Injury Underlies the Glomerulopathy of Dahl Salt-Hypertensive Rats and Is Reversed by Aldosterone Blocker2006 · 248 citations
  3. 3Differences in pharmacology and their translation into differences in clinical efficacy – a comparison of the renin angiotensin blocking agents irbesartan and losartan2009 · 12 citations
  4. 4Recommendations for Blood Pressure Measurement in Animals2005 · 64 citations
  5. 5Aliskiren, a Human Renin Inhibitor, Ameliorates Cardiac and Renal Damage in Double-Transgenic Rats2005 · 246 citations