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August 16, 2005HypertensionOpen Access

Aliskiren, a Human Renin Inhibitor, Ameliorates Cardiac and Renal Damage in Double-Transgenic Rats

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Why the study?

Does aliskiren ameliorate cardiac and renal damage in double-transgenic rats compared to untreated controls and valsartan?

Population

Six-week-old double transgenic rats for human renin and angiotensinogen genes, matched by albuminuria

Comparison

Aliskiren administered from week 6 through week 9 vs Untreated dTGR and valsartan treated rats

Design

Preclinical

Follow-up

3 weeks (from week 6 through week 9)

Authors

BPBernhard PilzESErdenechimeg ShagdarsurenMWMaren Wellner

Discussion

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Overview

Aliskiren attenuates cardiorenal injury in this rat model; leaves open translation to human hypertension and requires prospective trials.

Structured PICO

Does aliskiren ameliorate cardiac and renal damage in double-transgenic rats compared to untreated controls and valsartan?

P
Population
Six-week-old double transgenic rats (dTGR) for human renin and angiotensinogen genes, matched by albuminuria (2 mg per day)
I
Intervention
Aliskiren (3 and 0.3 mg/kg per day) administered from week 6 through week 9
C
Comparator
Untreated dTGR and valsartan (10 and 1 mg/kg per day) treated rats
O
Outcome
Blood pressure, serum creatinine, albuminuria, and mortality at week 9surrogate

In a double-transgenic rat model, the renin inhibitor aliskiren effectively lowered blood pressure and attenuated cardiac and renal damage, comparing favorably to valsartan.

Cite This Study

Pilz et al. (2005) studied this question.

synapsesocial.com/papers/6a80d5d11ece0ba82ce18bfdhttps://doi.org/10.1161/01.hyp.0000179573.91016.3f
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blood Pressure–Independent Effects in Rats With Human Renin and Angiotensinogen Genes2000 · 128 citations
  2. 2Blood Pressure Lowering in Essential Hypertension With an Oral Renin Inhibitor, Aliskiren2003 · 342 citations
  3. 3Angiotensin-Converting Enzyme Inhibition and AT1 Receptor Blockade Modify the Pressure-Natriuresis Relationship by Additive Mechanisms in Rats with Human Renin and Angiotensinogen Genes1999 · 39 citations
  4. 4Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats2005 · 157 citations
  5. 5Angiotensin II Suppression in Humans by the Orally Active Renin Inhibitor Aliskiren (SPP100)2002 · 409 citations