Key result
Adults with Down syndrome had significantly lower carotid-femoral pulse wave velocity compared to healthy controls (adjusted mean difference -0.93 m/s), primarily driven by chronic hypotension.
Why the study?
Do adults with Down syndrome have different surrogate markers of atherosclerosis compared to healthy adults?
Population
102 participants, community-dwelling in Madrid, Spain. Exclusion criteria included unoperated severe…
Comparison
Adults with Down syndrome vs Healthy adults
Design
Case-control
Authors
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Lower PWV in Down syndrome should not yet alter vascular risk assessment; leaves open hypotension's role in arterial health.
Case-Control (n=102)
No
Do adults with Down syndrome have different surrogate markers of atherosclerosis compared to healthy adults?
Mean Difference: -0.93 (95% CI -1.2–-0.6)
Absolute Event Rate: 5.9% vs 6.9%
p-value: p=<.01
Adults with Down syndrome appear to have lower arterial stiffness primarily due to chronic hypotension, and their subclinical atherosclerosis parameters do not correlate with traditional cardiovascular risk factors.
Parra et al. (2016) conducted a case-control in Down syndrome (n=102). Down syndrome vs. Healthy adults without Down syndrome was evaluated on Carotid-femoral pulse wave velocity (PWV) (MD -0.93, 95% CI -1.2 to -0.6, p=<.01). Adults with Down syndrome had significantly lower carotid-femoral pulse wave velocity compared to healthy controls (adjusted mean difference -0.93 m/s), primarily driven by chronic hypotension.
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