Key result
Severe acquired brain injury was associated with significantly reduced heart rate variability compared to healthy controls (SDNN 13 ms vs 40.3 ms, p<0.0001).
Why the study?
Does severe acquired brain injury reduce heart rate variability compared to healthy controls?
Case-Control (n=49)
Does severe acquired brain injury reduce heart rate variability compared to healthy controls?
Absolute Event Rate: 13% vs 40.3%
p-value: p=<0.0001
Severe acquired brain injury of various etiologies is associated with considerably reduced heart rate variability, indicating autonomic nervous system impairment.
Signals autonomic impairment in severe brain injury; hypothesis-generating for HRV monitoring before clinical adoption.
INTRODUCTION: Acquired brain injury (ABI) cause neural deficits. In addition to motor and cognitive deficits, the autonomic nervous system may be affected. This has been shown for neurorehabilitation patients with traumatic brain injury (TBI) by means of reduced heart rate variability (HRV). It was hypothesized that patient groups with other ABI aetiology (mainly stroke, subarachnoid haemorrhage and anoxia) would also present reduced HRV. METHODS: Patients consecutively admitted and severely ABI injured were considered for HRV measurements. HRV was extracted as a mean of four 5-minute ECG recordings at 6 pm, 10 pm, 2 am and 6 am the following day (scheduled resting periods). One 5-minute HRV recording from a sex- and age-matched group of healthy volunteers constituted control data. Standard deviation of normal-to-normal intervals (SDNN) and low frequency (LF) were primary HRV variables. RESULTS: Of 71 admitted patients, HRV was extracted from 49 patients. Patient SDNN and LF were reduced compared to controls (SDNN: 13 ms (CI = [10.8; 15.3]) vs 40.3 ms (CI = [36.6; 44.2]), p < 0.0001; LF: 29.4 ms² (CI = [19.8; 43.7]) vs 518 ms² (CI = [419; 639]), p < 0.0001). HRV appeared identical across ABI aetiology. CONCLUSION: It was found that HRV was considerably reduced in an heterogenic ABI patient group admitted for neurorehabilitation.
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Vistisen et al. (2013) conducted a case-control in Severe acquired brain injury (n=49). Severe acquired brain injury vs. Sex- and age-matched healthy volunteers was evaluated on Standard deviation of normal-to-normal intervals (SDNN) (p=<0.0001). Severe acquired brain injury was associated with significantly reduced heart rate variability compared to healthy controls (SDNN 13 ms vs 40.3 ms, p<0.0001).
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