Key result
Long-term maximal-dose PPI prescribing in older adults increased from 0.8% in 1997 to 23.6% in 2012, with significantly higher odds of receiving a maximal dose in 2012 (OR 6.30; 95% CI 5.76-6.88).
Cross-Sectional
Odds Ratio: 6.3 (95% CI 5.76–6.88)
Absolute Event Rate: 23.6% vs 0.8%
Long-term maximal-dose PPI prescribing has become highly prevalent in older adults and is not consistently aligned with gastrointestinal bleeding risk factors.
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May warrant deprescribing review in older adults on maximal-dose PPIs; leaves open optimal strategies and outcomes.
Moriarty et al. (2016) conducted a cross-sectional in Proton pump inhibitor (PPI) prescribing. Year 2012 vs. Year 1997 was evaluated on Prescription of a maximal PPI dose rather than a maintenance dose (OR 6.30, 95% CI 5.76-6.88). Long-term maximal-dose PPI prescribing in older adults increased from 0.8% in 1997 to 23.6% in 2012, with significantly higher odds of receiving a maximal dose in 2012 (OR 6.30; 95% CI 5.76-6.88).
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