Population
Male rats (4 months old)
Comparison
Exercise followed by 1, 3, 9, or 18 days of rest vs Sedentary control
Design
Preclinical, randomly assigned
Follow-up
Up to 18 days post-exercise
Authors
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Animal data indicate transient exercise cardioprotection against I/R injury up to 9 days; hypothesis-generating for human translation and optimal pre-event timing.
Exercise-induced cardioprotection against ischemia-reperfusion injury persists for up to 9 days after exercise cessation, outlasting the elevation of HSP72 and catalase.
Lennon et al. (2004) studied this question.
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