What question did this study set out to answer?

To evaluate factors associated with impaired sympathovagal balance in critically ill adults.

July 1, 2001Critical Care Medicine

Cardiac variability in critically ill adults: Influence of sepsis

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Why the study?

Does sepsis impair sympathovagal balance (measured by LF/HF ratio) in critically ill adults?

Population

41 critically ill adults with an expected duration of intensive care unit stay of >= 48 hours. Excluded…

Design

Cohort

Follow-up

Day after intensive care unit admission

Authors

MKMarion Korach-AndréIntegrated Cardio Metabolic Centre TSTarek SharsharDélégation Paris 5 IJIrène JarrinUniversité Paris Cité

Discussion

Member takes

Implication

Sepsis may impair sympathovagal balance in critically ill adults; leaves open whether LF/HF ratio aids sepsis detection.

Key Points

To evaluate factors associated with impaired sympathovagal balance in critically ill adults.
One-month inception cohort study conducted in a medical intensive care unit.
Enrollment of critically ill adults with an ICU stay of 48 hours or more, excluding those with arrhythmias.
Assessment of sympathovagal balance using the low-frequency/high-frequency ratio from heart rate signals.
Sepsis was identified as a strong independent predictor of a low-frequency/high-frequency ratio <1.50 (OR 3.63, 95% CI 1.47-9.01, p=0.005).
Forty-one patients were assessed, with 13 having sepsis and 28 without.
Likelihood ratio supports low-frequency/high-frequency ratio <1 as a potential diagnostic tool for sepsis.

Structured PICO

Does sepsis impair sympathovagal balance (measured by LF/HF ratio) in critically ill adults?

Population

41 critically ill adults with an expected duration of intensive care unit stay of >= 48 hours (13 with sepsis, 28 without sepsis). Excluded: patients with permanent arrhythmia or cardiac pacing.

Comparator

Critically ill adults without sepsis (n=28)

Outcome

Sympathovagal balance assessed by the low-frequency/high-frequency (LF/HF) ratio obtained from spectral components of heart rate signal on the day after ICU admissionsurrogate

Sepsis is independently associated with impaired sympathovagal balance (LF/HF ratio < 1.0) in critically ill adults, suggesting heart rate variability could serve as a diagnostic marker.

Cite This Study

Korach-André et al. (2001) studied this question.

synapsesocial.com/papers/6a77a9c8de5e3adfbdf72e16 https://doi.org/10.1097/00003246-200107000-00013

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Cardiac variability in critically ill adults: Influence of sepsis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cardiac variability in critically ill adults: Influence of sepsis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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