A Comprehensive Review on Green Synthesis of Silver Nanoparticles and its Biomedical Applications

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Metallic nanoparticles are novel types of functional material that altering human life in all aspects, made nanotechnology a viable field in biomedical research. One of the most extensive investigated nanomaterials among metallic nanoparticle of silver nanoparticles (AgNPs). The latest implementation and development of new technology has helped in new age, nano-revolution, which exposes the role of plants in green nanoparticle synthesis and attracted indisputable attention with the goal of producing stable and environmentally friendly nanoparticles. The extract of plants are emerging as a viable alternative to other traditional methods for synthesis of AgNPs because they are energy efficient, non-hazardous, environmental friendly and low cost as well as plants act as capping and reducing agents due to the presence of wide range of biomolecules. Electronics, clothes, industries of food, cosmetics, paints, sunscreens, bio sensing, medications, medical devices and drug delivery are just a few of the industries where biologically generated AgNPs are being used. AgNPs' broad bioactivities suggest that they could be used to combat a variety of microbial resistance issues. AgNPs have lately piqued scientists' interest due to their antiprotozoal, antibacterial, anticancer, antifungal, antiviral and anti-inflammatory properties. The purpose of this review is to go through green-mediated plant synthesis of AgNPs as well as the mechanistic elements of AgNP reduction and stabilization. AgNP characterization methods are examined, as well as AgNPs' broad-spectrum multifunctional activity and prospective biomedical applications. This review also considers the potential for human and ecosystem death traps as a result of expanded use of AgNPs, as well as the safety concerns surrounding their biological applications.