Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast.

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Mutation of a tyrosine localization signal in the cytosolic tail of yeast Kex2 protease disrupts Golgi retention and results in default transport to the vacuole.1992 · 212 citations
2. 2Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis.1988 · 167 citations
3. 3Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum.1985 · 310 citations
4. 4Rapid and efficient site-specific mutagenesis without phenotypic selection.1985 · 7,327 citations
5. 5Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation.1985 · 204 citations