Design, synthesis, antiproliferative activity and docking studies of quinazoline derivatives bearing oxazole or imidazole as potential EGFR inhibitors

Six series of quinazoline derivatives bearing oxazole or imidazole ( 8a–f , 9a–f , 10a–d , 11a–f , 12a–d and 13a–i ) were designed, synthesized and their IC ₅₀ values evaluated against three cancer cell lines (A549, MCF-7 and PC-3).