Population
Zebrafish (apoc2 and lpl mutants) and Apoc2 mutant mice models of hypertriglyceridemia and LPL deficiency
Comparison
Exogenous free fatty acid docosahexaenoic acid… vs Wild-type animals, inactive peptide, LDL, or…
Design
Preclinical
Authors
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LPL may regulate HSPC maintenance; hypothesis-generating for human hematopoiesis and requires mammalian validation before clinical consideration.
LPL-mediated hydrolysis of triglycerides to release free DHA is essential for hematopoietic stem progenitor cell maintenance and definitive hematopoiesis.
Liu et al. (2018) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: