What question did this study set out to answer?

To identify clinical, imaging, and inflammatory factors associated with hemorrhagic transformation despite early recanalization in patients undergoing mechanical thrombectomy for acute ischemic stroke.

August 30, 2023Journal of the Neurological SciencesOpen Access

Factors associated with hemorrhagic transformation after endovascular treatment despite early recanalization

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Authors

ACAntonio CiacciarelliPoliclinico Umberto I ATAgostino TessitoreUniversity of Messina GFGiulia FiumeCentro Neurolesi Bonino Pulejo

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Implication

Retrospective study identifies key risk factors for hemorrhagic transformation in acute ischemic stroke treated with thrombectomy, highlighting a critical recanalization time threshold of 7.67 hours.

Key Points

To identify clinical, imaging, and inflammatory factors associated with hemorrhagic transformation despite early recanalization in patients undergoing mechanical thrombectomy for acute ischemic stroke.
Retrospectively analyzed patients with known-onset large vessel occlusion treated with mechanical thrombectomy with or without intravenous thrombolysis (N=472 out of 874 screened).
Assessed non-contrast CT scans at 24 ± 12 hours post-procedure alongside baseline carotid intima-media thickness (CIMT), neutrophil-to-lymphocyte ratio (NLR), and Fazekas scores on FLAIR MRI.
Hemorrhagic transformation occurred in 211 of 472 patients (44.7%).
An onset-to-recanalization duration exceeding 7.67 hours was associated with a hemorrhagic transformation risk greater than 50%.
ASPECT-MRI score < 6, elevated NLR, and normal or mild CIMT independently predicted hemorrhagic transformation following recanalization.

Cite This Study

Ciacciarelli et al. (2023) studied this question.

synapsesocial.com/papers/6a77c2484fe2e6ffd8ecf02c https://doi.org/10.1016/j.jns.2023.120778

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Implication

Retrospective study identifies key risk factors for hemorrhagic transformation in acute ischemic stroke treated with thrombectomy, highlighting a critical recanalization time threshold of 7.67 hours.

Factors associated with hemorrhagic transformation after endovascular treatment despite early recanalization

Discussion

Member takes

Implication

Key Points

Cite This Study

Factors associated with hemorrhagic transformation after endovascular treatment despite early recanalization

Discussion

Member takes

Implication

Key Points

Cite This Study

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