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April 11, 2000Circulation

Identification of Coronary Thrombus With a IIb/IIIa Platelet Inhibitor Radiopharmaceutical, Technetium-99m DMP-444

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Why the study?

Does Technetium-99m DMP-444 accurately detect acute coronary thrombus by nuclear imaging in a canine model?

Population

Canine model with induced coronary thrombus, n=20.

Design

Preclinical

Authors

JMJoseph F. MitchelHartford Hospital DWDavid D. WatersGeneral Cardiology TLTianjie LaiShantou University

Discussion

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Implication

Supports Tc-99m DMP-444 feasibility for canine coronary thrombus imaging; leaves open translation to human detection.

Structured PICO

Does Technetium-99m DMP-444 accurately detect acute coronary thrombus by nuclear imaging in a canine model?

P

Population

Canine model with induced coronary thrombus (combinations of flow-limiting stenosis and 0 to 15 minutes of endothelial electrical stimulation in the left anterior descending coronary artery), n=20 (10 with positive images, 10 with negative images).

I

Intervention

Technetium-99m DMP-444 (a glycoprotein IIb/IIIa platelet inhibitor radiopharmaceutical) followed by nuclear imaging.

O

Outcome

Detection of platelet-rich thrombus confirmed postmortem by gross appearance, nuclear counts, and electron microscopy.surrogate

Tc-99m DMP-444 can accurately detect activated platelets in acute coronary thrombus via nuclear imaging in a canine model.

Cite This Study

Mitchel et al. (2000) studied this question.

synapsesocial.com/papers/6a77c2c3d3a6aa87c6bdefd6 https://doi.org/10.1161/01.cir.101.14.1643

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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

1Orally Effective CVS-1123 Prevents Coronary Artery Thrombosis in the Conscious Dog1996 · 22 citations
2The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes1992 · 3,734 citations
3The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes1992 · 2,722 citations
4Clinical Value of Acute Rest Technetium-99m Tetrofosmin Tomographic Myocardial Perfusion Imaging in Patients With Acute Chest Pain and Nondiagnostic Electrocardiograms1998 · 259 citations