Triarylbismuthanes as Threefold Aryl‐Transfer Reagents in Regioselective Cross‐Coupling Reactions with Bromopyridines and Quinolines

Cross‐coupling studies using bromopyridines and bromoquinolines with triarylbismuths as threefold coupling reagents in substoichiometric amounts under Pd‐catalysed conditions are disclosed. The reactivity was high with both mono‐ and dibromopyridyl substrates, and mono‐ and bis‐couplings were carried out regioselectively. A library of monoaryl and diaryl pyridines was formed in high yields. A one‐pot strategy provided a simple and straightforward synthesis of both symmetrical and unsymmetrical diarylpyridines. Arylations of 2‐bromo‐ and 3‐bromoquinolines were achieved with triarylbismuth reagents. This study demonstrates that triarylbismuths may be used as threefold arylating reagents for the synthesis of aryl pyridines and quinolines through couplings with bromopyridines and bromoquinolines under Pd‐catalysed conditions.