Population
Zebrafish models (wild-type and mutants with functional deficiencies)
Comparison
Genetic mutations causing functional deficiencies vs Wild-type zebrafish with normal circulation and…
Design
Preclinical
Authors
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No clinical implications from this animal study; hypothesis-generating for mechanical regulation of cardiomyocyte shape in cardiac development.
Regionally confined cardiomyocyte shape changes drive cardiac chamber emergence, regulated by a balance between extrinsic (blood flow) and intrinsic (contractility) physical forces.
Auman et al. (2007) studied this question.
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