Why the study?
Does the creation of a distal re-entry tear reduce false lumen dilation and lumen pressure differential in an ex vivo model of Type B aortic dissection?
Does the creation of a distal re-entry tear reduce false lumen dilation and lumen pressure differential in an ex vivo model of Type B aortic dissection?
The creation of a distal re-entry tear in Type B aortic dissection eliminates the lumen pressure differential but does not prevent false lumen dilation, suggesting that structural changes rather than local pressure gradients drive aortic expansion.
Lumen pressure differentials may promote post-dissection aortic expansion; leaves open whether modulating them improves outcomes in patients.
Mortality during follow-up after acute Type B aortic dissection is substantial with aortic expansion observed in over 59% of the patients. Lumen pressure differential is considered a prime contributing factor for aortic dilation after propagation. The objective of the study was to evaluate the relationship between changes in vessel geometry with and without lumen pressure differential post propagation in an ex vivo porcine model with comparison with patient clinical data. A pulse duplicator system was utilized to propagate the dissection within descending thoracic porcine aortic vessels for set proximal (%circumference of the entry tear: 40%, axial length: 2 cm) and re-entry (50% of distal vessel circumference) tear geometry. Measurements of lumen pressure differential were made along with quantification of vessel geometry (n = 16). The magnitude of mean lumen pressure difference measured after propagation was low (~ 5 mmHg) with higher pressures measured in false lumen and as anticipated the pressure difference approached zero after the creation of distal re-entry tear. False lumen Dissection Ratio (FDR) defined as arc length of dissected wall divided by arc length of dissection flap, had mean value of 1.59 ± 0.01 at pressure of 120/80 mmHg post propagation with increasing values with increase in pulse pressure that was not rescued with the creation of distal re-entry tear (p < 0.01). An average FDR of 1.87 ± 0.27 was measured in patients with acute Type B dissection. Higher FDR value (FDR = 1 implies zero dissection) in the presence of distal re-entry tear demonstrates an acute change in vessel morphology in response to the dissection independent of local pressure changes challenges the re-apposition of the aortic wall.
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Canchi et al. (2017) studied this question.
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