March 17, 2022Frontiers in Cardiovascular MedicineOpen Access

An in vitro Assessment of the Haemodynamic Features Occurring Within the True and False Lumens Separated by a Dissection Flap for a Patient-Specific Type B Aortic Dissection

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Structured PICO

Population

Patient-specific Stanford Type B aortic dissection phantom model based on a CT scan of a 30-year-old woman.

Intervention

In vitro simulation of physiological flow conditions using a pulsatile flow circuit, blood mimicking fluid, and an automated injection moulding system.

Outcome

Haemodynamic features including pressure distributions, flow patterns, and dissection flap movement.surrogate

A novel patient-specific in vitro phantom model of Type B aortic dissection successfully replicated physiological flow patterns, pressure distributions, and flap movements, providing a platform to assess future endovascular treatments.

Limitations

Accurate calculation of flowrates along true and false lumens was not possible using the ultrasound machine.

Discussion

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Implication

Enables preclinical endovascular device testing in Type B dissection; leaves open in vivo validation before clinical translation.

Cite This Study

Morris et al. (2022) studied this question.

synapsesocial.com/papers/6a812af1adfa6baaaee1b8f8 https://doi.org/10.3389/fcvm.2022.797829

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An in vitro Assessment of the Haemodynamic Features Occurring Within the True and False Lumens Separated by a Dissection Flap for a Patient-Specific Type B Aortic Dissection

Structured PICO

Limitations

Discussion

Implication

Cite This Study

An in vitro Assessment of the Haemodynamic Features Occurring Within the True and False Lumens Separated by a Dissection Flap for a Patient-Specific Type B Aortic Dissection

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider