What question did this study set out to answer?

To examine how stem cell factor and basic fibroblast growth factor interact to modulate granulocyte-macrophage colony-stimulating factor-mediated myeloid progenitor cell proliferation.

February 15, 1994BloodOpen Access

Stem cell factor and basic fibroblast growth factor are synergistic in augmenting committed myeloid progenitor cell growth

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Authors

JGJL GabriloveMemorial Sloan Kettering Cancer Center KWKenneth E. WhiteIndiana University School of Medicine ZRZiaur RahmanNational Institute of Pharmaceutical Education and Research

Discussion

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Implication

In vitro experimental study demonstrates synergistic myeloid progenitor expansion in human bone marrow cells, suggesting localized cytokine cooperation within hematopoietic niches.

Key Points

To examine how stem cell factor and basic fibroblast growth factor interact to modulate granulocyte-macrophage colony-stimulating factor-mediated myeloid progenitor cell proliferation.
Assayed clonogenic colony growth from low-density human bone marrow cells stimulated with granulocyte-macrophage colony-stimulating factor (GM-CSF).
Treated isolated low-density bone marrow and CD34+ progenitor cells with combinations of stem cell factor (SCF, 100 ng/mL) and basic fibroblast growth factor (bFGF, 100 ng/mL).
Adding 100 ng/mL SCF alongside 100 ng/mL bFGF significantly augmented GM-CSF-stimulated clonogenic growth derived from low-density bone marrow cells (P < .001).
Treatment of purified CD34+ progenitor cells with both cytokines produced a synergistic, up to sevenfold increase in detectable colony-forming units granulocyte-macrophage (P < .001).

Cite This Study

Gabrilove et al. (1994) studied this question.

synapsesocial.com/papers/6a77cbe82e130d02afecca53 https://doi.org/10.1182/blood.v83.4.907.907

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Implication

In vitro experimental study demonstrates synergistic myeloid progenitor expansion in human bone marrow cells, suggesting localized cytokine cooperation within hematopoietic niches.

Stem cell factor and basic fibroblast growth factor are synergistic in augmenting committed myeloid progenitor cell growth

Discussion

Member takes

Implication

Key Points

Cite This Study

Stem cell factor and basic fibroblast growth factor are synergistic in augmenting committed myeloid progenitor cell growth

Discussion

Member takes

Implication

Key Points

Cite This Study

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