Inflammation of the Atherosclerotic Cap and Shoulder of the Plaque Is a Common and Locally Observed Feature in Unruptured Plaques of Femoral and Coronary Arteries
Population
282 and 262 cross sections obtained from 74 coronary and 50 femoral arteries, respectively, to investigate…
Design
Cross-sectional
Authors
Discussion
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Implication
Frequent macrophage staining in stable femoral and coronary plaques cautions against inflammation imaging for vulnerability; leaves open prospective validation of diagnostic utility.
Structured PICO
P
Population
282 and 262 cross sections obtained from 74 coronary and 50 femoral arteries, respectively, to investigate nonruptured atherosclerotic plaques.
I
Intervention
Histological staining for macrophages and T lymphocytes (CD68 or acid phosphatase) in the cap and shoulder of the plaque.
O
Outcome
Prevalence and distribution (local versus general) of inflammatory cells in nonruptured atherosclerotic plaques.surrogate
Inflammation of the cap and shoulder of the plaque is a common, locally observed feature in unruptured atherosclerotic femoral and coronary arteries, which should be considered when using inflammation as a diagnostic target for vulnerable plaques.
Cite This Study
Pasterkamp et al. (1999) studied this question.