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January 1, 2005Clinical and Experimental Hypertension

The Bedtime Administration of Doxazosin Controls Morning Hypertension and Albuminuria in Patients with Type-2 Diabetes: Evaluation Using Home-Based Blood Pressure Measurements

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Why the study?

Does bedtime doxazosin reduce morning hypertension and albuminuria in patients with type-2 diabetes and morning hypertension?

Population

50 patients with type-2 diabetes and morning hypertension

Design

Cohort

Follow-up

mean 2.8 +/- 0.4 months

Authors

KKKyuzi KamoiJōetsu General HospitalTITomoo IkarashiNagara Medical Center

Discussion

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Implication

Should not yet alter practice in T2D morning hypertension; leaves open confirmation of bedtime doxazosin effects in randomized trials.

Structured PICO

Does bedtime doxazosin reduce morning hypertension and albuminuria in patients with type-2 diabetes and morning hypertension?

P
Population
50 patients with type-2 diabetes and morning hypertension
I
Intervention
Doxazosin oral once at bedtime for 1 to 3 months, mean dose 2.9 +/- 2.1 mg/day (range 1 to 8 mg/day)
O
Outcome
Home blood pressure (HBP) after awakening, clinic blood pressure (CBP), and urinary albumin excretion ratesurrogate

Bedtime administration of doxazosin effectively reduces morning hypertension and associated albuminuria in patients with type-2 diabetes.

Limitations

  • short-term trial

Cite This Study

Kamoi et al. (2005) studied this question.

synapsesocial.com/papers/6a77d037e29fd788c9f79702https://doi.org/10.1081/ceh-57438
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nighttime Dosing of Doxazosin Has Peak Effect on Morning Ambulatory Blood Pressure1994 · 109 citations
  2. 2Effect of an α-Adrenergic Blocker, and ACE Inhibitor and Hydrochlorothiazide on Blood Pressure and on Renal Function in Type 2 Diabetic Patients with Hypertension and Albuminuria1998 · 38 citations
  3. 3Usefulness of Home Blood Pressure Measurement in the Morning in Type 2 Diabetic Patients2002 · 98 citations
  4. 4Quantifying Risk of Adverse Clinical Events With One Set of Vital Signs Among Primary Care Patients with Hypertension2004 · 21 citations
  5. 5The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure1997 · 5,666 citations