Key result
Cilazapril and doxazosin both significantly reduced blood pressure (p=0.001), but only cilazapril significantly reduced albuminuria (350 to 205 mg/24 h; p=0.001).
Why the study?
Does cilazapril, doxazosin, or their combination reduce blood pressure and albuminuria in patients with type 2 diabetes and hypertension?
Population
76 patients with type 2 diabetes, hypertension (≥140/90 mm Hg), and albuminuria (≥30 mg/24 h)
Comparison
Cilazapril, doxazosin, or a combination of both… vs Active comparators
Design
RCT, randomized into three groups
Follow-up
Up to 12 months (three 4-month periods)
Authors
Loading...
ACEIs preferred over alpha-blockers for albuminuria reduction in diabetic hypertension despite similar BP effects; confirms renoprotection beyond BP lowering.
RCT (n=76)
randomized
Does cilazapril, doxazosin, or their combination reduce blood pressure and albuminuria in patients with type 2 diabetes and hypertension?
p-value: p=0.001
Both ACE inhibitors and alpha-blockers effectively lower blood pressure in diabetic patients, but ACE inhibitors provide superior reduction in albuminuria.
Rachmani et al. (1998) conducted an RCT in Type 2 diabetes with hypertension and albuminuria (n=76). Cilazapril, doxazosin, or combination vs. Active comparators (cross-over design) was evaluated on Blood pressure and albuminuria (p=0.001). Cilazapril and doxazosin both significantly reduced blood pressure (p=0.001), but only cilazapril significantly reduced albuminuria (350 to 205 mg/24 h; p=0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: