Effects of Angiotensin Converting Enzyme Inhibitors and Calcium Antagonists on Atrial Natriuretic Peptide Release and Action and on Albumin Excretion Rate in Hypertensive Insulin-Dependent Diabetic Patients

32 hypertensive insulin-dependent diabetic patients with an altered albumin excretion rate, and 8 normal subjects matched for sex, age, and weight serving as controls.

Cilazapril (2.5 to 5.0 mg once daily), verapamil (sustained release 120 to 240 mg once daily), combined cilazapril and verapamil, or nifedipine (long acting 20 to 40 mg twice daily), evaluated alongside a saline load (2 mmol/kg over 90 min).

Normal matched controls (for baseline saline load response) and within-patient comparisons between different antihypertensive regimens.

Natriuretic response and atrial natriuretic peptide (ANP) release to saline load, and albumin excretion rate.surrogate