January 1, 2003Journal of Hypertension

Disparate effects of angiotensin II antagonists and calcium channel blockers on albuminuria in experimental diabetes and hypertension

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Why the study?

Does valsartan monotherapy or combination with calcium channel blockers reduce albuminuria in an experimental model of diabetic nephropathy?

Population

Accelerated model of diabetic nephropathy in rats

Comparison

Valsartan monotherapy or combination therapy of… vs Diabetic control and comparison between…

Design

Preclinical

Authors

BDBelinda J. DavisDepartment of Biodiversity, Conservation and Attractions ZCZemin CaoBaker Heart and Diabetes Institute MGMarc de GasparoGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Valsartan monotherapy may confer BP-independent renoprotection in diabetic nephropathy models; hypothesis-generating and leaves open clinical translation.

Structured PICO

Does valsartan monotherapy or combination with calcium channel blockers reduce albuminuria in an experimental model of diabetic nephropathy?

Population

Accelerated model of diabetic nephropathy in rats

Intervention

Valsartan monotherapy or combination therapy of valsartan with calcium channel blockers (amlodipine or verapamil)

Comparator

Diabetic control and comparison between monotherapy and combination regimens

Outcome

Progression of renal disease (albumin excretion rate, glomerulosclerosis) and expression of nephrinsurrogate

Valsartan monotherapy provided superior renoprotection compared to equihypotensive combination therapy with calcium channel blockers in a rat model of diabetic nephropathy.

Cite This Study

Davis et al. (2003) studied this question.

synapsesocial.com/papers/6a72a85326770c2b8de187bf https://doi.org/10.1097/00004872-200301000-00031

Topics

Hypertension management

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Implication

Valsartan monotherapy may confer BP-independent renoprotection in diabetic nephropathy models; hypothesis-generating and leaves open clinical translation.

Disparate effects of angiotensin II antagonists and calcium channel blockers on albuminuria in experimental diabetes and hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Disparate effects of angiotensin II antagonists and calcium channel blockers on albuminuria in experimental diabetes and hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider