Adiponectin inhibits LPS-induced NF-κB activation and IL-6 production and increases PPARγ2 expression in adipocytes

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Population

Primary adipocytes from pig subcutaneous adipose tissue and 3T3-L1 adipocytes

Comparison

Adiponectin in the presence or absence of… vs Control (no treatment) or LPS alone

Design

Preclinical

Authors

Discussion

Adiponectin modulation merits further adipocyte inflammation studies; leaves open human cardiometabolic translation.

Population

Primary adipocytes from pig subcutaneous adipose tissue and 3T3-L1 adipocytes

Intervention

Adiponectin (30 microg/ml) in the presence or absence of lipopolysaccharide (LPS; 10 microg/ml) or interferon-gamma

Comparator

Control (no treatment) or LPS alone

Outcome

NF-kappaB activation, IL-6 expression, TNF-alpha mRNA expression, and PPARgamma2 mRNA expressionsurrogate

Adiponectin acts as a local anti-inflammatory regulator in adipocytes by suppressing NF-κB activation and upregulating PPARγ2.

Ajuwon et al. (2004) studied this question.

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