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June 1, 1981Clinical Orthopaedics and Related Research

Current Concepts of the Physiology and Biochemistry of Calcification

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Authors

ABAdele L. BoskeyRutgers, The State University of New Jersey

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Implication

Review reveals cellular regulation of mineral crystal deposition in extracellular matrices, highlighting the coordinated roles of matrix vesicles, collagen, and regulatory proteins.

Key Points

  • To synthesize physiological and biochemical concepts governing how cellular activity and matrix components regulate mineral crystal deposition in biological tissues.
  • Narrative synthesis evaluating cellular ion handling, mitochondrial transport, and extracellular matrix composition during tissue calcification.
  • Cells direct extracellular matrix calcification by responding to hormonal cues, releasing accumulated calcium and phosphate from mitochondria, and secreting matrix-modifying macromolecules.
  • Matrix vesicles provide the initial nucleation sites for mineral deposition in diverse tissues, while collagen scaffolds support hydroxyapatite crystal formation.
  • Proteoglycans, glycoproteins, enzymes, phosphoproteins, and lipids collectively modulate the rate, spatial organization, and structural integrity of mineralization.

Cite This Study

Adele L. Boskey (1981) studied this question.

synapsesocial.com/papers/6a77da5fd3a6aa87c6bdfdfehttps://doi.org/10.1097/00003086-198106000-00036
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Also Consider

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  1. 1Proteoglycans and Biomineralization of Bone and Dentin2026
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  5. 5Nucleic Acids as Emerging Regulators of Calcium Phosphate Biomineralization2026