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November 15, 1998Blood

Flavopiridol Induces Apoptosis in Chronic Lymphocytic Leukemia Cells Via Activation of Caspase-3 Without Evidence of bcl-2 Modulation or Dependence on Functional p53

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Authors

JBJohn C. ByrdCincinnati VA Medical CenterCSCharlotte ShinnUniversity of California, San DiegoJWJamie K. WaselenkoOncology Hematology Care

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Byrd et al. (1998) studied this question.

synapsesocial.com/papers/6a77dd122e130d02afecd578https://doi.org/10.1182/blood.v92.10.3804
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Also Consider

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  1. 1Bcl-2,Bax andp53 expression in B-CLL in relation toin vitro survival and clinical progression1996 · 141 citations
  2. 2Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX1996 · 164 citations
  3. 3Immunolocalization of the ICE/Ced-3–Family Protease, CPP32 (Caspase-3), in Non-Hodgkin's Lymphomas, Chronic Lymphocytic Leukemias, and Reactive Lymph Nodes1997 · 93 citations
  4. 4Growth Inhibition With Reversible Cell Cycle Arrest of Carcinoma Cells by Flavone L86-82751992 · 353 citations
  5. 5The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis1997 · 4,761 citations