Two types of delayed rectifying K+ channels in atrial cells of guinea pig heart.

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Population

Single guinea pig atrial myocytes

Design

Preclinical

Authors

Discussion

Advances understanding of atrial repolarization in animal models; hypothesis-generating for K+ channel-targeted therapies in human AF.

Population

Single guinea pig atrial myocytes

Intervention

Repolarizing voltage pulses to cell-free patches from atrial cell membrane

Outcome

Characterization of delayed rectifying K+ channels (single channel conductances, reversal potential, deactivation kinetics)surrogate

This basic science study identifies two distinct types of K+ channels responsible for delayed rectifying K+ currents in guinea pig atrial myocytes.

Horie et al. (1990) studied this question.

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