A series of 5-aryl furfurals and aryl thiophene-2-carboxaldehydes was synthesized. To this end, efficient and effective palladium-catalyzed C−C bond-forming reactions were carried out at room temperature in aqueous media. This mild process allowed the cross-coupling reaction of the bromides to occur in the presence of electrophilic functional groups, which is a valuable advantage over previously reported methods.
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Bussolari et al. (1999) studied this question.
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