Heterogeneity of contractile proteins. Purification and characterization of two species of troponin T from rabbit fast skeletal muscle.

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Population

Rabbit fast skeletal muscle (erector spinae, gastrocnemius, and plantaris)

Design

Preclinical

Authors

Discussion

Distinguishes TnT sequence variants from modifications in rabbit muscle; leaves open functional roles in human disease.

Population

Rabbit fast skeletal muscle (erector spinae, gastrocnemius, and plantaris)

Intervention

Purification and characterization of troponin T species (Tn-T1f and Tn-T2f)

Outcome

Characterization of differences between Tn-T1f and Tn-T2f

Identified two distinct species of troponin T in rabbit fast skeletal muscle that likely arise from different genes or alternative splicing.

Briggs et al. (1984) studied this question.

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