Key result
Curcumin protects against agent-induced cardiotoxicity in preclinical models, but human clinical trial data remain lacking.
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Curcumin, the major phenolic compound in turmeric, shows preventive effects in various diseases. Curcumin is commonly found in rhizome of the Curcuma species and traditionally used in herbal medicine. Numeros studies has indicated that curcumin posses protective effects against toxic agents in various systems including cardiovascular. This study found that curcumin may be effective in cardiovascular diseases induced by toxic agents including Streptozotocin, Doxorubicin, Cyclosporin A, Methotrexate, Isoproterenol, Cadmium, Diesel exhaust particle, Nicotine, Hydrogen peroxide, and tert- Butyl hydroperoxide. However, due to the lake of information on human, further studies are needed to determine the efficacy of curcumin as an antidote agent. The present study aimed to critically review the recent literature data from that regarding the protective effects of curcumin against agents-induced cardiovascular toxicity.
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Farkhondeh et al. (2016) conducted a review in Agents-induced cardiovascular toxicity. Curcumin was evaluated on Protective effects against agents-induced cardiovascular toxicity. Curcumin shows protective effects against cardiovascular toxicity induced by agents such as doxorubicin, streptozotocin, and cyclosporin A, though human clinical data remain lacking.
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