January 1, 1996AJP Cell Physiology

A mitochondrial uncoupler increases KCa currents but decreases KV currents in pulmonary artery myocytes

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Population

Rat pulmonary artery myocytes

Design

Preclinical

Authors

XYX. J. YuanUniversity of Maryland, Baltimore TSTakao SugiyamaFujieda Municipal General Hospital WGW. F. GoldmanKaplan Medical Center

Discussion

Member takes

Implication

Caution advised before clinical translation; leaves open mitochondrial modulation of pulmonary vascular K+ currents in vivo.

Structured PICO

Population

Rat pulmonary artery myocytes

Intervention

Carbonyl cyanide p-trifluoromethoxyphenyl-hydrazone (FCCP) (3-5 microM)

Outcome

K+ currents (IK) and intracellular free Ca2+ concentration ([Ca2+]i)surrogate

In rat pulmonary artery myocytes, the mitochondrial uncoupler FCCP increases KCa currents through intracellular Ca2+ release but decreases KV currents likely via inhibition of oxidative ATP production.

Cite This Study

Yuan et al. (1996) studied this question.

synapsesocial.com/papers/6a77e6db2e130d02afecdc85 https://doi.org/10.1152/ajpcell.1996.270.1.c321

View Full Paper

Ask AI

Bookmark

A mitochondrial uncoupler increases KCa currents but decreases KV currents in pulmonary artery myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A mitochondrial uncoupler increases KCa currents but decreases KV currents in pulmonary artery myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider