Why the study?
To review clinical evidence and molecular mechanisms behind myocardial recovery following LVAD placement and share institutional protocols from 2 major US medical centers.
This review summarizes the clinical evidence and molecular mechanisms behind myocardial recovery following LVAD placement, along with institutional protocols from two major US medical centers.
LVAD recovery mechanisms merit targeted trials; leaves open translation to routine BTR strategies.
Left ventricular assist devices (LVADs) have revolutionized the management of patients with advanced heart failure refractory to medical therapy. Current indications of LVADs include Bridge to Transplantation (BTT), Destination Therapy (DT) for long-term use, Bridge to the Decision (BTD) used as a temporary measure, and lastly Bridge to Recovery (BTR). Here, we briefly review the clinical evidence and the molecular mechanisms behind myocardial recovery following LVAD placement. We also share institutional protocols used at 2 major medical centers in the USA.
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Arshad et al. (2022) studied this question.
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