Why the study?
The mechanisms underlying Pitx2-modulated arrhythmogenesis and the variable effectiveness of antiarrhythmic drugs in patients with or without impaired Pitx2 expression remained unclear.
In silico modeling demonstrates that Pitx2 deficiency promotes atrial fibrillation via electrical and structural remodeling, and that flecainide's efficacy involves preventing spontaneous calcium release.
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Pitx2-modulated AF models suggest variable AAD response; leaves open genotype-guided therapy pending clinical validation.
Bai et al. (2020) studied this question.
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