Why the study?
Does SK3 channel overexpression alter atrial action potential repolarization and predispose to atrial arrhythmias in a mouse model?
Population
Mouse model with site-specific insertion of a tetracycline-based genetic switch in the 5' untranslated…
Comparison
Overexpression of SK3 channel and treatment with… vs Normal profile of SK3 expression
Design
Preclinical
Authors
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May inform SK3-targeted AF therapies; leaves open clinical translation from mouse models.
Does SK3 channel overexpression alter atrial action potential repolarization and predispose to atrial arrhythmias in a mouse model?
SK3 channels play a critical role in atrial action potential repolarization, with overexpression shortening APD90 and predisposing to atrial arrhythmias in a mouse model.
Zhang et al. (2013) studied this question.
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