Why the study?
Does ACE inhibitor therapy improve one-year survival in older patients with depressed LVEF following acute myocardial infarction, regardless of baseline renal function?
Population
20,902 Medicare beneficiaries aged 65 years and older with a documented left ventricular ejection fraction…
Comparison
ACE inhibitor prescribed at hospital discharge. vs No ACE inhibitor prescribed at hospital discharge.
Design
Cohort
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
ACE inhibitor at discharge was associated with improved survival; supports randomized trials in older post-MI patients with low LVEF regardless of renal function.
Structured PICO
Does ACE inhibitor therapy improve one-year survival in older patients with depressed LVEF following acute myocardial infarction, regardless of baseline renal function?
P
Population
20,902 Medicare beneficiaries aged 65 years and older with a documented left ventricular ejection fraction of less than 40% following a confirmed acute myocardial infarction.
I
Intervention
ACE inhibitor prescribed at hospital discharge.
C
Comparator
No ACE inhibitor prescribed at hospital discharge.
O
Outcome
One-year survival.hard clinical
ACE inhibitors improve 1-year survival in older patients with depressed LVEF post-myocardial infarction, and this benefit persists even in those with moderate renal insufficiency.
Cite This Study
Frances et al. (2000) studied this question.