Key result
Intra-arterial norepinephrine reduces exercise skeletal muscle blood flow by up to ~65%.
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Flaim et al. (1979) studied Active hyperemia during static continuous exercise in skeletal muscle (n=18). Intra-arterial norepinephrine vs. Isotonic saline alone (control) was evaluated on Skeletal muscle blood flow (BF), oxygen consumption (VO2), and arteriovenous oxygen difference (A-VO2) at rest and during exercise. Intra-arterial norepinephrine during exercise attenuated skeletal muscle blood flow by 7-65%, widened arteriovenous O2 difference by 22-35%, and reduced O2 consumption by 56% at the highest dose.
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